Age-related macular degeneration (AMD) is a common and devastating disease that can
result in severe visual dysfunction. Over the last decade, great progress has been made in …

Retinal endothelial cells line the arborizing microvasculature that supplies and drains the
neural retina. The anatomical and physiological characteristics of these endothelial cells are …

The earliest blood vessels in mammalian embryos are formed when endothelial cells
differentiate from angioblasts and coalesce into tubular networks. Thereafter, the …

The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of
chorioretinal diseases, many of which are poorly understood. Recent advances in the field of …

Angiogenesis of the microvasculature is central to the etiology of many diseases including
proliferative retinopathy, age-related macular degeneration and cancer. A mouse model of …

Retinal vascular basement membrane (BM) thickening is an early structural abnormality of
diabetic retinopathy (DR). Recent studies suggest that BM thickening contributes to the DR …

The outer blood-retina barrier (oBRB), crucial for the survival and the proper functioning of
the overlying retinal layers, is disrupted in numerous diseases affecting the retina, leading to …

The choriocapillaris, a dense capillary network located at the posterior pole of the eye, is
essential for supporting normal vision, supplying nutrients, and removing waste products …

Age-related macular degeneration (AMD) afflicts one out of every 40 individuals worldwide,
causing irreversible central blindness in millions. The transformation of various tissue layers …

The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in regulating cell
proliferation, migration and differentiation in a variety of human cells and is one of four …