Osteogenesis imperfecta is a phenotypically and molecularly heterogeneous group of
inherited connective tissue disorders that share similar skeletal abnormalities causing bone …

A new paradigm has emerged for osteogenesis imperfecta as a collagen-related disorder.
The more prevalent autosomal dominant forms of osteogenesis imperfecta are caused by …

Punishment is a popular tool when governing commons in situations where free riders
would otherwise take over. It is well known that sanctioning systems, such as the police and …

The extracellular matrix represents a complex alloy of variable members of diverse protein
families defining structural integrity and various physiological functions. The most abundant …

A major roadblock to successful organ bioengineering is the need for a functional vascular
network within the engineered tissue. Here, we describe the fabrication of three …

The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular
basement membrane (BM) and the interstitial ECM is identified as a crucial component of …

Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver.
While some view fibroblasts in adult tissues as nothing more than primitive mesenchymal …

The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

Collagens and proteins with collagen-like domains form large superfamilies in various
species, and the numbers of known family members are increasing constantly. Vertebrates …

Serpins are a superfamily of proteins, whose membership is based on the presence of a
single common core domain consisting of three β-sheets and 8-9 R-helices, and with a set of …