The Cannabis plant has been used for many of years as a medicinal agent in the relief of
pain and seizures. It contains approximately 540 natural compounds including more than …

Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …

The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

Cannabinoids have a long history of consumption for recreational and medical reasons. The
primary active constituent of the hemp plant Cannabis sativa is Δ9-tetrahydrocannabinol (Δ9 …

After their discovery, the two known cannabinoid receptors, CB1 and CB2, have been the
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …

The cannabinoid receptor family currently includes twotypes: CB 1, characterized in
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …

The cannabinoid CB1 receptor has been shown to be the primary site of action for
cannabinoid-induced effects on the central nervous system. Activation of this receptor has …

Chronic Δ9-tetrahydrocannabinol (Δ9-THC) administration produces tolerance to
cannabinoid effects, but alterations in signal transduction that mediate these changes are …

Prior studies from this laboratory have shown that the psychoactive ingredient in marijuana,
Δ9-tetrahydrocannabinol (THC), interferes with short-term memory (1–3) in both delayed …

Cannabinoids, including Δ9-tetrahydrocannabinol (THC), bind to receptors that couple to G
io-proteins and inhibit adenylyl cyclase. However, like other G-protein-coupled receptors …