Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer

J Bian, M Dannappel, C Wan, R Firestein - Cells, 2020 - mdpi.com
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

[HTML][HTML] The role of SOX family members in solid tumours and metastasis

D Grimm, J Bauer, P Wise, M Krüger… - Seminars in cancer …, 2020 - Elsevier
Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

[HTML][HTML] Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/β-catenin …

Y Cui, F Zhang, C Zhu, L Geng, T Tian, H Liu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Lung cancer is the most common and aggressive tumor in the world. Long non-coding RNA
small nucleolar RNA host gene 1 (lncRNA SNHG1) play critical roles in the progression of …

Deep top-down proteomics revealed significant proteoform-level differences between metastatic and nonmetastatic colorectal cancer cells

EN McCool, T Xu, W Chen, NC Beller, SM Nolan… - Science …, 2022 - science.org
Understanding cancer metastasis at the proteoform level is crucial for discovering previously
unknown protein biomarkers for cancer diagnosis and drug development. We present the …

High recovery FASP applied to the proteomic analysis of microdissected formalin fixed paraffin embedded cancer tissues retrieves known colon cancer markers

JR Wisniewski, P Ostasiewicz… - Journal of proteome …, 2011 - ACS Publications
Proteomic analysis of samples isolated by laser capture microdissection from clinical
specimens requires sample preparation and fractionation methods suitable for small …

Oncogenicity of the developmental transcription factor Sox9

A Matheu, M Collado, C Wise, L Manterola, L Cekaite… - Cancer research, 2012 - AACR
SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box
transcription factor, plays critical roles during embryogenesis and its activity is required for …

SOX9 drives WNT pathway activation in prostate cancer

F Ma, H Ye, HH He, SJ Gerrin, S Chen… - The Journal of …, 2016 - Am Soc Clin Investig
The transcription factor SOX9 is critical for prostate development, and dysregulation of SOX9
is implicated in prostate cancer (PCa). However, the SOX9-dependent genes and pathways …

SOX9: An emerging driving factor from cancer progression to drug resistance

M Panda, SK Tripathi, BK Biswal - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …

SOX9 drives the epithelial–mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway

JQ Huang, FK Wei, XL Xu, SX Ye, JW Song… - Journal of translational …, 2019 - Springer
Background The distant metastasis of cancer cells is a risk factor for tumor lethality and poor
prognosis in non-small-cell lung carcinoma (NSCLC). Increased SOX9 expression has been …

[HTML][HTML] Tumor-associated macrophages promote tumor metastasis via the TGF-β/SOX9 axis in non-small cell lung cancer

S Zhang, D Che, F Yang, C Chi, H Meng, J Shen, L Qi… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Tumor-associated macrophages (TAMs), most of which display the
immunosuppressive M2 phenotype, affect the tumor microenvironment and promote …