The RNA-dependent RNA polymerases (RdRPs) encoded by the RNA viruses are a unique
class of nucleic acid polymerases. Each viral RdRP contains a 500–600 residue catalytic …

Like all positive strand RNA viruses, the picornaviruses replicate their genomes using a
virally encoded RNA-dependent RNA polymerase enzyme known as 3D pol. Over the past …

Positive-sense RNA viruses encode RNA-dependent RNA polymerases (RdRps) essential
for genomic replication. With the exception of the large nidoviruses, such as coronaviruses …

Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key
residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine polymerase …

Positive-strand RNA viruses replicate their genomes using virally encoded RNA-dependent
RNA polymerases (RdRP) with a common active-site structure and closure mechanism upon …

Viral RNA-dependent RNA polymerases are considered to be low-fidelity enzymes,
providing high mutation rates that allow for the rapid adaptation of RNA viruses to different …

Enterovirus infections have become a serious public health threat to young children, leading
to hand-foot-and-mouth disease and more severe nervous system diseases. Due to the lack …

RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure
genome replication within the infected cells. RdRP function is critical not only for the virus life …

The genus Enterovirus of the family Picornaviridae contains many important human
pathogens (eg, poliovirus, coxsackievirus, rhinovirus, and enterovirus 71) for which no …

RNA-dependent RNA polymerases play a vital role in the growth of RNA viruses where they
are responsible for genome replication, but do so with rather low fidelity that allows for the …