Aquaporins (AQP) are integral membrane proteins that serve as channels in the transfer of
water, and in some cases, small solutes across the membrane. They are conserved in …

To prevent dehydration, terrestrial animals and humans have developed a sensitive and
versatile system to maintain their water homeostasis. In states of hypernatremia or …

Protein phosphorylation plays a key role in vasopressin signaling in the renal-collecting
duct. Large-scale identification and quantification of phosphorylation events triggered by …

This review outlines recent advances related to the molecular mechanisms and pathways of
aquaporin-2 (AQP2) water channel trafficking. AQP2 is a fascinating protein, whose sorting …

In renal collecting ducts, a vasopressin-induced cAMP increase results in the
phosphorylation of aquaporin-2 (AQP2) water channels at Ser-256 and its redistribution from …

The kidney collecting duct is an important renal tubular segment for regulation of body water
homeostasis and urine concentration. Water reabsorption in the collecting duct principal …

Water excretion is regulated in large part through the regulation of osmotic water
permeability of the renal collecting duct epithelium. Water permeability is controlled by …

Seven aquaporin water channels are expressed in human kidneys, and they have key roles
in maintaining body water homeostasis. Impairment of their function can result in …

Principal cells lining renal collecting ducts control the fine-tuning of body water homeostasis
by regulating water reabsorption through the water channels aquaporin-2 (AQP2) …

In the kidney aquaporin-2 (AQP2) provides a target for hormonal regulation of water
transport by vasopressin. Short-term control of water permeability occurs via vesicular …