Bone defects combined with tumors, infections, or other bone diseases are challenging in
clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but …

Successful materials design for bone-tissue engineering requires an understanding of the
composition and structure of native bone tissue, as well as appropriate selection of …

In spite of the considerable achievements in the field of regenerative medicine in the past
several decades, osteochondral defect regeneration remains a challenging issue among …

Osteoporosis is a chronic disease characterized by low bone mass caused by increased
bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or …

Bone biomaterials play a vital role in bone repair by providing the necessary substrate for
cell adhesion, proliferation, and differentiation and by modulating cell activity and function. In …

Highlights•Alternative bone regenerative therapeutics are needed.•Ions have been
proposed to regenerate skeletal tissue.•Drug delivery systems have been studied to deliver …

Various bifunctional scaffolds have recently been developed to address the reconstruction of
tumor‐initiated bone defects. Such scaffolds are usually composed of a near‐infrared (NIR) …

Bone defects caused by trauma, severe infection, tumor resection and skeletal abnormalities
are common osteoporotic conditions and major challenges in orthopedic surgery, and there …

With the development of bone tissue engineering bio-scaffold materials by adding metallic
ions to improve bone healing have been extensively explored in the past decades …

Hydrogels have attracted much attention for biomedical and pharmaceutical applications
due to the similarity of their biomimetic structure to the extracellular matrix of natural living …