Toll-like receptors (TLRs), a class of pattern recognition proteins, play an integral role in the
modulation of systemic inflammatory responses. Cerebrovascular diseases (CVDs) are a …

Glaucoma is a collection of diseases that lead to an irreversible vision loss due to damage of
retinal ganglion cells (RGCs). Although the underlying events leading to RGC death are not …

Aims or purpose Glaucoma is the leading cause of vision loss and blindness in the world.
Elucidating the pathogenesis of glaucoma and developing effective treatment should be the …

Background Dexmedetomidine has been reported to play an efficient role on multi-organ
protection. Our study aims to investigate the neuroprotective of dexmedetomidine …

Objective Hypoxia-induced factor 1a (HIF-1a) and Toll-like receptor 4 (TLR4) are involved in
pre-eclampsia (PE) pathogenesis. However, little is known about their relationships. This …

In glaucoma, latest studies revealed an involvement of the complement system with and
without an elevated intraocular pressure. In the experimental autoimmune glaucoma model …

Background Cisplatin-based chemotherapy is the first line of treatment for bladder cancer.
However, cisplatin induces muscle wasting associated with NF-κB and cancer cachexia …

Prothymosin alpha (ProTα) was discovered to be a necrosis inhibitor from the conditioned
medium of a primary culture of rat cortical neurons under starved conditions. This protein …

Chronic neuro-inflammation is involved in the death of retinal ganglion cells (RGCs) in
glaucoma. The aim of this study is to determine whether wogonin can suppress inflammatory …

Purpose The aim of this study was to investigate the effect of minocycline (MC) on the
survival of retinal ganglion cells (RGCs) in an ischemic-reperfusion (I/R) injury model of …