Cancer vaccines: toward the next breakthrough in cancer immunotherapy

Y Igarashi, T Sasada - Journal of immunology research, 2020 - Wiley Online Library
Until now, three types of well‐recognized cancer treatments have been developed, ie,
surgery, chemotherapy, and radiotherapy; these either remove or directly attack the cancer …

Therapeutic cancer vaccines: past, present, and future

C Guo, MH Manjili, JR Subjeck, D Sarkar… - Advances in cancer …, 2013 - Elsevier
Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

Targeting dendritic cells with biomaterials: developing the next generation of vaccines

ST Reddy, MA Swartz, JA Hubbell - Trends in immunology, 2006 - cell.com
Current vaccine and immunotherapy technology faces ongoing challenges in both efficacy
and practicality: many chronic diseases cannot yet be addressed by vaccination, and …

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

RK DeLong, CM Reynolds, Y Malcolm… - Nanotechnology …, 2010 - Taylor & Francis
Nanotechnology has virtually exploded in the last few years with seemingly limitless
opportunity across all segments of our society. If gene and RNA therapy are to ever realize …

Administration routes affect the quality of immune responses: a cross-sectional evaluation of particulate antigen-delivery systems

D Mohanan, B Slütter, M Henriksen-Lacey… - Journal of Controlled …, 2010 - Elsevier
Particulate delivery systems such as liposomes and polymeric nano-and microparticles are
attracting great interest for developing new vaccines. Materials and formulation properties …

Advances in the design and delivery of peptide subunit vaccines with a focus on toll-like receptor agonists

M Black, A Trent, M Tirrell, C Olive - Expert review of vaccines, 2010 - Taylor & Francis
Considerable success has been made with many peptide antigen formulations, and peptide-
based vaccines are emerging as the next generation of prophylactic and remedial …

Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines

SL Demento, AL Siefert, A Bandyopadhyay… - Trends in …, 2011 - cell.com
Vaccine development has progressed significantly and has moved from whole
microorganisms to subunit vaccines that contain only their antigenic proteins. Subunit …

Virion-like delivery particles for self-replicating RNA molecules

A Geall, C Mandi, D O'hagan, M Singh - US Patent 11,291,635, 2022 - Google Patents
Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated
within a small particle. The RNA encodes an immunogen of interest, and the particle may …

Biomimetic delivery with micro‐and nanoparticles

SC Balmert, SR Little - Advanced materials, 2012 - Wiley Online Library
The nascent field of biomimetic delivery with micro‐and nanoparticles (MNP) has advanced
considerably in recent years. Drawing inspiration from the ways that cells communicate in …

mRNA as a versatile tool for exogenous protein expression

AN Kuhn, T Beissert, P Simon, B Vallazza… - Current gene …, 2012 - ingentaconnect.com
Several viral and non-viral vectors have been developed for exogenous protein expression
in specific cells. Conventionally, this purpose is achieved through the use of recombinant …