Ovarian cancer encompasses a collection of neoplasms with distinct clinicopathological and
molecular features and prognosis. Despite there being a variety of ovarian cancer subtypes …

There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Background The major clinical challenge in the treatment of high-grade serous ovarian
cancer (HGSOC) is the development of progressive resistance to platinum-based …

High‐grade serous ovarian cancer (HGSC) is characterized by poor outcome, often
attributed to the emergence of treatment‐resistant subclones. We sought to measure the …

Cancer progression in humans is difficult to infer because we do not routinely sample
patients at multiple stages of their disease. However, heterogeneous breast tumors provide …

In this review we examine the mechanisms (causes) underlying the increased glucose
consumption observed in tumors within a teleological context (consequences). In other …

In cancer research and personalized medicine, new tissue culture models are needed to
better predict the response of patients to therapies. With a concern for the small volume of …

Malignant ascites constitute a unique tumor microenvironment providing a physical structure
for the accumulation of cellular and acellular components. Ascites is initiated and …

In this review we summarize recent advances in the histopathological diagnostic criteria and
molecular pathology of the main subtypes of ovarian surface epithelial carcinoma. These …

Epithelial ovarian cancers (EOCs) are sensitive to chemotherapy but will ultimately relapse
and develop drug resistance. The origin of EOC recurrence has been elusive due to intra …