Molecular mechanisms underlying the effects of statins in the central nervous system
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, commonly referred to as
statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary …
statins, are widely used in the treatment of dyslipidaemia, in addition to providing primary …
Statins in depression: an evidence-based overview of mechanisms and clinical studies
R De Giorgi, N Rizzo Pesci, A Quinton… - Frontiers in …, 2021 - frontiersin.org
Background: Depression is a leading cause of disability, burdened by high levels of non-
response to conventional antidepressants. Novel therapeutic strategies targeting non …
response to conventional antidepressants. Novel therapeutic strategies targeting non …
Zebrafish: A new promise to study the impact of metabolic disorders on the brain
B Ghaddar, N Diotel - International Journal of Molecular Sciences, 2022 - mdpi.com
Zebrafish has become a popular model to study many physiological and pathophysiological
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …
Simvastatin versus atorvastatin for improving mild to moderate depression in post-coronary artery bypass graft patients: A double-blind, placebo-controlled …
SH Abbasi, P Mohammadinejad… - Journal of Affective …, 2015 - Elsevier
Background A decreased risk of developing depression has been reported among statin
users. Aside from their lipid-lowering effects, statins are considered immunomodulatory …
users. Aside from their lipid-lowering effects, statins are considered immunomodulatory …
In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major …
M Haghighi, S Khodakarami, L Jahangard… - Journal of psychiatric …, 2014 - Elsevier
Background The administration of statins seems to be a promising new avenue in the
treatment of patients suffering from major depressive disorder (MDD), though patients …
treatment of patients suffering from major depressive disorder (MDD), though patients …
Statin for mood and inflammation among adult patients with major depressive disorder: an updated meta-analysis
Introduction Several small sample-sized clinical trials have demonstrated a beneficial effect
of statin on depressive mood among major depressive disorder (MDD) patients. However …
of statin on depressive mood among major depressive disorder (MDD) patients. However …
Statin use and depression risk: a systematic review and meta-analysis
MC Lee, TR Peng, CH Lee, JY Wang, JA Lee… - Journal of Affective …, 2021 - Elsevier
Background Evidence regarding whether statin use is associated with depression is
inconsistent. Therefore, we performed a meta-analysis to investigate this association …
inconsistent. Therefore, we performed a meta-analysis to investigate this association …
Drug repurposing may generate novel approaches to treating depression
ME Ebada - Journal of Pharmacy and Pharmacology, 2017 - academic.oup.com
Objectives The breakthrough advancements in scientific medical research have greatly
improved our understanding of the pathogenesis of depression, encouraging drug …
improved our understanding of the pathogenesis of depression, encouraging drug …
Do statins have antidepressant effects?
O Köhler-Forsberg, C Gasse, M Berk, SD Østergaard - Cns Drugs, 2017 - Springer
Statins are used widely in primary and secondary prevention of cardiovascular disease; a
treatment effect that has long been thought to be due to their cholesterol-lowering properties …
treatment effect that has long been thought to be due to their cholesterol-lowering properties …
The effect of atorvastatin on cognition and mood in bipolar disorder and unipolar depression patients: a secondary analysis of a randomized controlled trial
Objectives Statins have recently been linked to having effects on cognition and mood in
mood disorders, though results are mixed. In this paper, we use data from a recent …
mood disorders, though results are mixed. In this paper, we use data from a recent …