Co-evolution techniques were originally conceived to assist in protein structure prediction by
inferring pairs of residues that share spatial proximity. However, the functional relationships …

Evolutionary pressure on residue interactions, intramolecular or intermolecular, that are
important for protein structure or function can lead to covariance between the two positions …

Pathogenic fungal diseases in crops are mediated by the release of effector proteins that
facilitate infection. Characterising the structure of these fungal effectors is vital to …

Molecular replacement (MR) is the predominant route to solution of the phase problem in
macromolecular crystallography. Where the lack of a suitable homologue precludes …

Bacterial competence, which can be natural or induced, allows the uptake of exogenous
double stranded DNA (dsDNA) into a competent bacterium. This process is known as …

Crystallographic phasing strategies increasingly require the exploration and ranking of
many hypotheses about the number, types and positions of atoms, molecules and/or …

Molecular replacement (MR) is the predominant route to solution of the phase problem in
macromolecular crystallography. Although routine in many cases, it becomes more effortful …

Covariance-based predictions of residue contacts and inter-residue distances are an
increasingly popular data type in protein bioinformatics. Here we present ConPlot, a web …

Proteins isolated from natural sources can be composed of a mixture of isoforms with similar
physicochemical properties that coexist in the final steps of purification. Yet, even where …

Background Despite the rapid progress of protein residue contact prediction, predicted
residue contact maps frequently contain many errors. However, information of residue …