RNA structural dynamics as captured by molecular simulations: a comprehensive overview

J Sponer, G Bussi, M Krepl, P Banáš, S Bottaro… - Chemical …, 2018 - ACS Publications
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

[HTML][HTML] Astrochemistry and astrobiology: materials science in wonderland?

M d'Ischia, P Manini, M Moracci, R Saladino… - International Journal of …, 2019 - mdpi.com
Astrochemistry and astrobiology, the fascinating disciplines that strive to unravel the origin of
life, have opened unprecedented and unpredicted vistas into exotic compounds as well as …

Catalytic synthesis of polyribonucleic acid on prebiotic rock glasses

CA Jerome, HJ Kim, SJ Mojzsis, SA Benner, E Biondi - Astrobiology, 2022 - liebertpub.com
Reported here are experiments that show that ribonucleoside triphosphates are converted to
polyribonucleic acid when incubated with rock glasses similar to those likely present 4.3–4.4 …

Formation of nucleobases in a Miller–Urey reducing atmosphere

M Ferus, F Pietrucci, AM Saitta… - Proceedings of the …, 2017 - National Acad Sciences
The Miller–Urey experiments pioneered modern research on the molecular origins of life,
but their actual relevance in this field was later questioned because the gas mixture used in …

Direct prebiotic pathway to DNA nucleosides

JS Teichert, FM Kruse, O Trapp - Angewandte Chemie, 2019 - Wiley Online Library
It is assumed that RNA played a key role in the origin of life, and the transition to more
complex but more stable DNA for continuous information storage and replication requires …

[HTML][HTML] The key role of meteorites in the formation of relevant prebiotic molecules in a formamide/water environment

L Rotelli, JM Trigo-Rodríguez, CE Moyano-Cambero… - Scientific reports, 2016 - nature.com
We show that carbonaceous chondrite meteorites actively and selectively catalyze the
formation of relevant prebiotic molecules from formamide in aqueous media. Specific …

Mechanochemical Activation of Iron Cyano Complexes: A Prebiotic Impact Scenario for the Synthesis of α‐Amino Acid Derivatives

C Bolm, R Mocci, C Schumacher, M Turberg… - Angewandte …, 2018 - Wiley Online Library
Mechanochemical activation of iron cyano complexes by ball milling results in the formation
of HCN, which can be trapped and incorporated into α‐aminonitriles. This prebiotic impact …

[HTML][HTML] From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth

F Sauer, M Haas, C Sydow, AF Siegle… - Nature …, 2021 - nature.com
The formation of peptide bonds is one of the most important biochemical reaction steps.
Without the development of structurally and catalytically active polymers, there would be no …

Geological and geochemical constraints on the origin and evolution of life

NH Sleep - Astrobiology, 2018 - liebertpub.com
The traditional tree of life from molecular biology with last universal common ancestor
(LUCA) branching into bacteria and archaea (though fuzzy) is likely formally valid enough to …

[HTML][HTML] Prebiotic synthesis initiated in formaldehyde by laser plasma simulating high-velocity impacts

M Ferus, F Pietrucci, AM Saitta, O Ivanek… - Astronomy & …, 2019 - aanda.org
Context. It is well known that hydrogen cyanide and formamide can universally be
considered as key molecules in prebiotic synthesis. Despite the fact that formamide has …