Neonates, infants, and children differ from adults in many aspects, not just in age, weight,
and body composition. Growth, maturation and environmental factors affect drug kinetics …

Understanding the dose–concentration–effect relationship is a fundamental component of
clinical pharmacology. Interpreting data arising from observations of this relationship …

Wide-Ranging Coverage of Parametric Modeling in Linear and Nonlinear Mixed Effects
Models Mixed Effects Models for the Population Approach: Models, Tasks, Methods and …

Background In response to the World Health Organization call for research on alternative
routes for tranexamic acid (TXA) administration in women with postpartum haemorrhage, we …

Irrespective of whether a drug is in development or already available on the market, the
current paradigm for paediatric dose selection does not guarantee safe and effective dosing …

mrgsolve is an open‐source R package available on the Comprehensive R Archive
Network. It combines R and C++ coding for simulation from hierarchical, ordinary differential …

Population pharmacokinetic (PK)–pharmacodynamic (PKPD) models are increasingly used
in drug development and in academic research; hence, designing efficient studies is an …

Febuxostat is a xanthine oxidoreductase inhibitor that has been developed to treat chronic
gout. In healthy subjects, the pharmacokinetic parameters of febuxostat after multiple oral …

Abstract Background and Objective Nonlinear mixed-effect models (NLMEMs) are
increasingly used for the analysis of longitudinal studies during drug development. When …

A prospective multicenter study was conducted to characterize the pharmacokinetics (PK)
and pharmacodynamics (PD) of fludarabine plasma (f-ara-a) and intracellular triphosphate (f …