Computational models in cardiology
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …
Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care
Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …
Interleukin-6-Mediated-Ca2+ Handling Abnormalities Contributes to Atrial Fibrillation in Sterile Pericarditis Rats
J Liao, S Zhang, S Yang, Y Lu, K Lu, Y Wu… - Frontiers in …, 2021 - frontiersin.org
Pre-existing Ca2+ handling abnormalities constitute the arrhythmogenic substrate in
patients developing postoperative atrial fibrillation (POAF), a common complication after …
patients developing postoperative atrial fibrillation (POAF), a common complication after …
Mechanisms and drug development in atrial fibrillation
Atrial fibrillation is a highly prevalent cardiac arrhythmia and the most important cause of
embolic stroke. Although genetic studies have identified an increasing assembly of AF …
embolic stroke. Although genetic studies have identified an increasing assembly of AF …
[HTML][HTML] Cardiac dynamics: alternans and arrhythmogenesis
G Tse, ST Wong, V Tse, YT Lee, HY Lin, JM Yeo - Journal of Arrhythmia, 2016 - Elsevier
Pre-existing heterogeneities present in cardiac tissue are essential for maintaining the
normal electrical and mechanical functions of the heart. Exacerbation of such …
normal electrical and mechanical functions of the heart. Exacerbation of such …
Low‐level tragus stimulation modulates atrial alternans and fibrillation burden in patients with paroxysmal atrial fibrillation
K Kulkarni, JP Singh, KA Parks… - Journal of the …, 2021 - Am Heart Assoc
Background Low‐level tragus stimulation (LLTS) has been shown to significantly reduce
atrial fibrillation (AF) burden in patients with paroxysmal AF. P‐wave alternans (PWA) is …
atrial fibrillation (AF) burden in patients with paroxysmal AF. P‐wave alternans (PWA) is …
Computational modeling of electrophysiology and pharmacotherapy of atrial fibrillation: recent advances and future challenges
M Vagos, IGM van Herck, J Sundnes… - Frontiers in …, 2018 - frontiersin.org
The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …
[HTML][HTML] Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation–remodeled hearts
T Liu, F Xiong, XY Qi, J Xiao, L Villeneuve, I Abu-Taha… - JCI insight, 2020 - ncbi.nlm.nih.gov
Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ handling, promoting ectopic
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …
beat formation. We examined the effects of AF-associated remodeling on Ca 2+-related …
Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation
The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …
ion channels, transporters and signalling pathways to cardiac electrophysiology …
How computer simulations of the human heart can improve anti‐arrhythmia therapy
NA Trayanova, KC Chang - The Journal of physiology, 2016 - Wiley Online Library
Over the last decade, the state‐of‐the‐art in cardiac computational modelling has
progressed rapidly. The electrophysiological function of the heart can now be simulated with …
progressed rapidly. The electrophysiological function of the heart can now be simulated with …