Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

The Blood–brain barrier (BBB), present at the level of the endothelium of cerebral blood
vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is …

The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

The blood–brain barrier (BBB) is a dynamic and complex interface between blood and the
central nervous system that strictly controls the exchanges between the blood and brain …

The blood–brain barrier (BBB) is the specialized system of brain microvascular endothelial
cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain …

▪ Abstract Tight junctions form continuous intercellular contacts controlling solute movement
through the paracellular pathway across epithelia. Paracellular barriers vary among …

While endothelial cell (EC) function is influenced by mitochondrial metabolism, the role of
mitochondrial dynamics in angiogenesis, the formation of new blood vessels from existing …

Tight junctions (TJs) regulate the passage of ions and molecules through the paracellular
pathway in epithelial and endothelial cells. TJs are highly dynamic structures whose degree …

The blood-brain barrier (BBB) is a highly specialized structural and biochemical barrier that
regulates the entry of blood-borne molecules into brain, and preserves ionic homeostasis …

The concept of the CNS as an immune-privileged organ has led to a common
misunderstanding that it is not an active immunological organ, guarded from its …