Structure and function of respiratory syncytial virus surface glycoproteins
JS McLellan, WC Ray, ME Peeples - Challenges and opportunities for …, 2013 - Springer
The two major glycoproteins on the surface of the respiratory syncytial virus (RSV) virion, the
attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of …
attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of …
Novel antigens for RSV vaccines
BS Graham, K Modjarrad, JS McLellan - Current opinion in immunology, 2015 - Elsevier
Highlights•There are multiple neutralizing antibody binding sites on F protein and at least
one on G protein.•The most potent neutralizing antibodies recognize sites exclusively on the …
one on G protein.•The most potent neutralizing antibodies recognize sites exclusively on the …
The RSVPreF3-AS01 vaccine elicits broad neutralization of contemporary and antigenically distant respiratory syncytial virus strains
L Sacconnay, J De Smedt, V Rocha-Perugini… - Science Translational …, 2023 - science.org
The RSVPreF3-AS01 vaccine, containing the respiratory syncytial virus (RSV) prefusion F
protein and the AS01 adjuvant, was previously shown to boost neutralization responses …
protein and the AS01 adjuvant, was previously shown to boost neutralization responses …
Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers
KA Swanson, EC Settembre… - Proceedings of the …, 2011 - National Acad Sciences
Respiratory syncytial virus (RSV), the main cause of infant bronchiolitis, remains a major
unmet vaccine need despite more than 40 years of vaccine research. Vaccine candidates …
unmet vaccine need despite more than 40 years of vaccine research. Vaccine candidates …
Infants infected with respiratory syncytial virus generate potent neutralizing antibodies that lack somatic hypermutation
E Goodwin, MSA Gilman, D Wrapp, M Chen… - Immunity, 2018 - cell.com
Respiratory syncytial virus (RSV) is a leading cause of infant mortality, and there are
currently no licensed vaccines to protect this vulnerable population. A comprehensive …
currently no licensed vaccines to protect this vulnerable population. A comprehensive …
A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein
A Tang, Z Chen, KS Cox, HP Su, C Callahan… - Nature …, 2019 - nature.com
Respiratory syncytial virus (RSV) infection is the leading cause of hospitalization and infant
mortality under six months of age worldwide; therefore, the prevention of RSV infection in all …
mortality under six months of age worldwide; therefore, the prevention of RSV infection in all …
Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules
A Hultberg, NJ Temperton, V Rosseels, M Koenders… - PloS one, 2011 - journals.plos.org
For efficient prevention of viral infections and cross protection, simultaneous targeting of
multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) …
multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) …
A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein
Respiratory syncytial virus (RSV) remains a major human pathogen, infecting the majority of
infants before age two and causing re-infection throughout life. Despite decades of RSV …
infants before age two and causing re-infection throughout life. Despite decades of RSV …
Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein
JS McLellan - Current opinion in virology, 2015 - Elsevier
Highlights•X-ray crystal structures of prefusion and postfusion RSV F have been
determined.•Antibodies specific for the prefusion conformation are extremely potent.•Select …
determined.•Antibodies specific for the prefusion conformation are extremely potent.•Select …
Structure of a major antigenic site on the respiratory syncytial virus fusion glycoprotein in complex with neutralizing antibody 101F
JS McLellan, M Chen, JS Chang, Y Yang, A Kim… - Journal of …, 2010 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is a major cause of pneumonia and bronchiolitis in infants
and elderly people. Currently there is no effective vaccine against RSV, but passive …
and elderly people. Currently there is no effective vaccine against RSV, but passive …