Several experimental evidences show that prions are non-conventional pathogens, which
physical support consists only in proteins. This finding raised questions regarding the …

In order to assess the susceptibility of bank voles to chronic wasting disease (CWD), we
inoculated voles carrying isoleucine or methionine at codon 109 (Bv109I and Bv109M …

The factors that modulate the transmissibility of Transmissible Spongiform Encephalopathies
(TSE) and the approaches for the study of their zoonotic potential are reviewed. The paper …

To assess the effectiveness of the strategies implemented in the European Union (EU) to
control Classical scrapie (CS), epidemiological data have been compared in the context of …

Abstract Bovine Spongiform Encephalopathy (BSE) is the only animal prion which has been
recognized as a zoonotic agent so far. The identification of BSE in two goats raised the need …

Natural scrapie transmission from infected ewes to their lambs is thought to occur by the oral
route around the time of birth. However the hypothesis that scrapie transmission can also …

Prion diseases are fatal transmissible neurodegenerative diseases of various mammalian
species. Central to these conditions is the conversion of the normal host prion protein PrPC …

Mammalian prions propagate by template-directed misfolding and aggregation of normal
cellular prion related protein PrPC as it converts into disease-associated conformers …

The diversity of goat scrapie strains in Europe has recently been studied using bioassays in
a wide collection of rodent models, resulting in the classification of classical scrapie into four …

Background The infectious agent responsible for the bovine spongiform encephalopathy
(BSE) epidemic in Great Britain is a transmissible spongiform encephalopathy (TSE) strain …