Developing new drugs is a complex, time‐consuming, and expensive process, essential to
identify potential pharmacokinetic issues in the early stages to avoid investment in …

In-vitro models are available in the literature for predicting the volume of distribution at
steady-state (Vd ss) of drugs. The mechanistic model refers to the tissue composition-based …

The process of passive drug absorption from the gastrointestinal tract is still poorly
understood and modelled. Additionally, the rapidly evolving field of pharmaceutics demands …

The cell membrane is an important regulator for the cytotoxicity of chemotherapeutic agents.
However, the biochemical and biophysical effects that occur in the membrane under the …

Delicaflavone (DF), a natural active ingredient from Selaginella doederleinii Hieron, has
been reported to have favorable anticancer effects and is thus considered a potential …

Cellular or tumor dormancy, identified recently as one of the main reasons behind post‐
therapy recurrence, can be caused by diverse reasons. Chemotherapy has recently been …

It is important for elucidating the regulation mechanism of life activities, as well as for the
prevention, diagnosis, and drug design of diseases, to study protein–protein interactions …

Extensive research has been conducted on biomimetic interfaces mimicking the complex
and diverse microenvironment of cell membranes to gain insights into bioactive compound …

Terbutaline sulphate (TS) is a selective short-acting β 2 adrenoceptor agonist used for
asthma treatment. The pharmacological activity of TS depends on its binding to the …

Camptothecin (CPT) is a potent anticancer drug, and its putative oral administration is
envisioned although difficult due to physiological barriers that must be overcome. A …