The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing
Translocator protein (TSPO, 18 kDa) is an evolutionary, well-preserved, and tryptophan-rich
169-amino-acid protein which localizes on the contact sites between the outer and inner …
169-amino-acid protein which localizes on the contact sites between the outer and inner …
Evaluation of advanced, pathophysiologic new targets for imaging of CNS
The inadequate information about the in vivo pathological, physiological, and neurological
impairments, as well as the absence of in vivo tools for assessing brain penetrance and the …
impairments, as well as the absence of in vivo tools for assessing brain penetrance and the …
[18F]BIBD-239: 18F-Labeled ER176, a Positron Emission Tomography Tracer Specific for the Translocator Protein
H Chen, Z Jiang, X Cheng, W Zheng, Y Sun… - Molecular …, 2022 - ACS Publications
[11C] ER176 has adequate sensitivity to image the human brain translocator protein (TSPO)
in all three genotypes by positron emission tomography (PET). However, its clinical …
in all three genotypes by positron emission tomography (PET). However, its clinical …
Colony Stimulating Factor-1 Receptor: An emerging target for neuroinflammation PET imaging and AD therapy
Although neuroinflammation is a significant pathogenic feature of many neurologic
disorders, its precise function in-vivo is still not completely known. PET imaging enables the …
disorders, its precise function in-vivo is still not completely known. PET imaging enables the …
Design of a deuterated TSPO tracer and its application in glioma and atherosclerotic imaging
Y Huang, Z Jiang, L Zhang, Z Yu, C Li, H Chen… - New Journal of …, 2025 - pubs.rsc.org
[18F] BIBD-239-d2 was designed by applying deuterated [18F] BIBD-239 to improve its
stability. In vitro assays demonstrated that [18F] BIBD-239-d2 binds to TSPO with a high …
stability. In vitro assays demonstrated that [18F] BIBD-239-d2 binds to TSPO with a high …
Comparison of PIC and EDTA-coupled acetamidobenzoxazolone probes as a specific marker for a 18 kDa protein (TSPO)
2-(Bis (pyridin-2-ylmethyl) amino) acetic acid (PIC) and ethylenediaminetetraacetic acid
(EDTA) vehicle-based acetamidobenzoxazolone probes have been evaluated for the …
(EDTA) vehicle-based acetamidobenzoxazolone probes have been evaluated for the …
Acetamidobenzoxazolone conjugated DOTA system for assessing 18 kDa translocator protein during pulmonary inflammation
Translocator protein (TSPO) is well known inflammatory target. We have designed a new
molecule DOTA-MBP. In-silico studies have been performed to evaluate the binding affinity …
molecule DOTA-MBP. In-silico studies have been performed to evaluate the binding affinity …
Imaging Agents for PET of Inflammatory Bowel Disease: A Review
F Rezazadeh, AP Kilcline, NT Viola - Journal of Nuclear Medicine, 2023 - Soc Nuclear Med
Inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn disease,
is a chronic inflammatory disorder resulting from an aberrant immune response, though its …
is a chronic inflammatory disorder resulting from an aberrant immune response, though its …
Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers
The translocator protein 18-kDa (TSPO) is a mitochondrial membrane protein that is
previously identified as the peripheral benzodiazepine receptor (PBR). Furthermore, it plays …
previously identified as the peripheral benzodiazepine receptor (PBR). Furthermore, it plays …
Current advances in the structure–activity relationship (SAR) analysis of the old/new 18-kDa translocator protein ligands
The translocator protein 18 kDa (TSPO) is a crucial external mitochondrial protein involved
in cholesterol translocation, which is essential for steroid production. As a primary marker of …
in cholesterol translocation, which is essential for steroid production. As a primary marker of …