Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M Jing, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

The Human Gene Mutation Database (HGMD®): optimizing its use in a clinical diagnostic or research setting

PD Stenson, M Mort, EV Ball, M Chapman, K Evans… - Human genetics, 2020 - Springer
Abstract The Human Gene Mutation Database (HGMD®) constitutes a comprehensive
collection of published germline mutations in nuclear genes that are thought to underlie, or …

[HTML][HTML] Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

NE Reticker-Flynn, W Zhang, JA Belk, PA Basto… - Cell, 2022 - cell.com
For many solid malignancies, lymph node (LN) involvement represents a harbinger of
distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as …

A proximity-dependent biotinylation map of a human cell

CD Go, JDR Knight, A Rajasekharan, B Rathod… - Nature, 2021 - nature.com
Compartmentalization is a defining characteristic of eukaryotic cells, and partitions distinct
biochemical processes into discrete subcellular locations. Microscopy and biochemical …

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

I Sturmlechner, C Zhang, CC Sine, EJ van Deursen… - Science, 2021 - science.org
INTRODUCTION Complex multicellular organisms are subject to a myriad of cellular
stresses, which can be managed through cell-intrinsic adaptation and repair mechanisms …

Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle

W Wang, F Vilella, P Alama, I Moreno, M Mignardi… - Nature Medicine, 2020 - nature.com
In a human menstrual cycle the endometrium undergoes remodeling, shedding and
regeneration, all of which are driven by substantial gene expression changes in the …

QSAR without borders

EN Muratov, J Bajorath, RP Sheridan… - Chemical Society …, 2020 - pubs.rsc.org
Prediction of chemical bioactivity and physical properties has been one of the most
important applications of statistical and more recently, machine learning and artificial …

Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification

M Dapas, A Dunaif - Endocrine reviews, 2022 - academic.oup.com
Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

K Blin, S Shaw, K Steinke, R Villebro… - Nucleic acids …, 2019 - academic.oup.com
Secondary metabolites produced by bacteria and fungi are an important source of
antimicrobials and other bioactive compounds. In recent years, genome mining has seen …

The PSIPRED protein analysis workbench: 20 years on

DWA Buchan, DT Jones - Nucleic acids research, 2019 - academic.oup.com
The PSIPRED Workbench is a web server offering a range of predictive methods to the
bioscience community for 20 years. Here, we present the work we have completed to update …