Regulatory Mechanisms of Aging Through the Nutritional and Metabolic Control of Amino Acid Signaling in Model Organisms

F Obata, M Miura - Annual Review of Genetics, 2024 - annualreviews.org
Life activities are supported by the intricate metabolic network that is fueled by nutrients.
Nutritional and genetic studies in model organisms have determined that dietary restriction …

Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10

MH Dalhat, S Narayan, H Serio, D Arango - Oncogene, 2024 - nature.com
Chemical modifications of ribonucleotides significantly alter the physicochemical properties
and functions of RNA. Initially perceived as static and essential marks in ribosomal RNA …

Pathogenic tau induces an adaptive elevation in mRNA translation rate at early stages of disease

G Zuniga, S Katsumura, J De Mange, P Ramirez… - Aging cell, 2024 - Wiley Online Library
Alterations in the rate and accuracy of messenger RNA (mRNA) translation are associated
with aging and several neurodegenerative disorders, including Alzheimer's disease and …

Gut-to-brain regulation of Drosophila aging through neuropeptide F, insulin, and juvenile hormone

J Chen, M Nouzova, FG Noriega, M Tatar - Proceedings of the National …, 2024 - pnas.org
Dietary restriction (DR) slows aging in many animals, while in some cases, the sensory
signals from diet alone are sufficient to retard or accelerate lifespan. The digestive tract is a …

Feeding a rich diet supplemented with the translation inhibitor cycloheximide decreases lifespan and ovary size in Drosophila

HJ Hwang, RT Cox - Biology Open, 2024 - journals.biologists.com
Drosophila oogenesis has long been an important model for understanding myriad cellular
processes controlling development, RNA biology and patterning. Flies are easily fed drugs …

Targeting eIF2α in TBI-induced traumatic optic neuropathy: Effects of Salubrinal and the Integrated Stress Response Inhibitor.

S Hetzer, R Bellary, JN Torrens, RF Grimaldi… - bioRxiv, 2024 - biorxiv.org
Traumatic brain injury (TBI) can induce traumatic axonal injury in the optic nerve, which is
referred to as traumatic optic neuropathy (TON). TON occurs in up to 5% of TBI cases and …

The adolescent and the axon: Assessing the role of the ER in a murine model of traumatic optic neuropathy

SM Hetzer - 2024 - search.proquest.com
Traumatic brain injury (TBI) is an incredibly heterogenous pathology, yet many of the current
mechanisms under exploration involve a common phenotype, traumatic axonal injury (TAI) …

[引用][C] Protein translation rates are negatively correlated with lifespan in in-bred Drosophila strains

HS Kim, MM Hardiman… - The Journals of …, 2024 - academic.oup.com
Protein translation (PT) is an essential cellular process that plays critical roles in growth and
development. PT occurs at high levels in early adulthood but declines with age across …