Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer's disease pathology

YF Lee, AN Russ, Q Zhao, SJ Perle, M Maci… - Scientific reports, 2023 - nature.com
Patients with Alzheimer's disease (AD) exhibit non-rapid eye movement (NREM) sleep
disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in …

Calcium sensor Yellow Cameleon 3.6 as a tool to support the calcium hypothesis of Alzheimer's disease

MR Miller, YF Lee, KV Kastanenka - Alzheimer's & Dementia, 2023 - Wiley Online Library
INTRODUCTION Alzheimer's disease (AD) is a neurodegenerative disease with increasing
relevance as dementia cases rise. The etiology of AD is widely debated. The Calcium …

NB-02 Protects Neurons and Astrocytes from Oligomeric Amyloid-β-Mediated Damage

MR Miller, L Lariviere, GJ Pagnier… - Journal of …, 2024 - journals.sagepub.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease with limited
therapeutic strategies. NB-02 is a novel botanical drug that has shown promise as a …

Exploring pharmacokinetics and herb-drug interactions of an herbal extract mixture derived from Poria cocos and Morus alba L.

SY Yun, JI Seo, SZ Choi, JY Ryu, AY Park… - Journal of …, 2024 - Springer
Abstract Purpose Poria cocos and Morus alba L., recognized as traditional Chinese
medicines (TCMs), have gained attention for their diverse pharmacological effects. An …

Rescue of sleep-dependent brain rhythm function to slow Alzheimer's disease

YF Lee - 2022 - search.proquest.com
Patients with Alzheimer's disease (AD) experience sleep disturbances, including disruption
in slow-wave sleep (SWS). Slow oscillations (≤ 1 Hz), a brain rhythm prevalent during SWS …