Somatostatin: Linking Cognition and Alzheimer's Disease to Therapeutic Targeting

KE Sandoval, KA Witt - Pharmacological Reviews, 2024 - pharmrev.aspetjournals.org
Over four decades of research support the link between Alzheimer9s disease (AD) and
somatostatin (somatotropin-releasing inhibitory factor, SRIF). SRIF and SRIF-expressing …

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease

E Chartampila, KS Elayouby, P Leary, JJ LaFrancois… - eLife, 2024 - elifesciences.org
Maternal choline supplementation (MCS) improves cognition in Alzheimer's disease (AD)
models. However, the effects of MCS on neuronal hyperexcitability in AD are unknown. We …