Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

The IUBMB enzyme classification system, available at the IUBMB ExplorEnz website, uses a
four‐component number (the EC number) that identifies an enzyme in terms of reaction …

Monensin A is a prototypical natural polyether polyketide antibiotic. It acts by binding a metal
cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A …

Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …

Metabolism has long been considered as a relatively stiff set of biochemical reactions. This
somewhat outdated and dogmatic view has been challenged over the last years, as multiple …

Aryl-alcohol oxidases (AAOs) are FAD-containing enzymes that oxidize a broad range of
aromatic as well as aliphatic allylic alcohols to aldehydes. Their broad substrate spectrum …

Flavin-dependent monooxygenases (FDMOs) are known for their remarkable versatility and
for their crucial roles in various biological processes and applications. Extensive research …

Angiotensin-converting enzyme inhibitors are widely used for treatment of hypertension and
related diseases. Here, six karnamicins E1-E6 (1–6), which bear fully substituted …

Prenylated indole alkaloids featuring spirooxindole rings possess a 3 R or 3 S carbon
stereocenter, which determines the bioactivities of these compounds. Despite the …

Abstract Kynurenine‐3‐monooxygenase (KMO) is a mitochondrial enzyme involved in the
eukaryotic kynurenine pathway (KP), which is the major catabolic route of tryptophan. KMO …