All animals heal, and the ability to heal is requisite for human health. One aspect of repair
that has always been considered to be essential for adequate healing is the creation of a …

In wound healing, individual cells' behaviors coordinate movement toward the wound center
to restore small or large barrier defects. The migration of epithelial cells as a continuous …

Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular
and cellular specializations. To explore genomic mechanisms that control this specialization …

The incidence of allergic diseases has increased over the past 50 years, likely due to
environmental factors. However, the nature of these factors and the mode of action by which …

Unlike classical voltage-gated sodium (NaV) channels, NaX has been characterized as a
voltage-insensitive, tetrodotoxin-resistant, sodium (Na+)-activated channel involved in …

A major function of the skin is the regulation of body temperature by sweat secretions. Sweat
glands secrete water and salt, especially NaCl. Excreted water evaporates, cooling the skin …

Hyperosmotic stress occurs in several diseases, but its long-term effects are largely
unknown. We used sorbitol-treated human fibroblasts in 3D culture to study the …

Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated
molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic …

Toxins and venom components that target voltage-gated sodium (Na V) channels have
evolved numerous times due to the importance of this class of ion channels in the normal …

Damage to epidermis results in loss of barrier function and resultant pathological
inflammatory signaling, triggering further damage to the skin. Here we investigate …