Various diseases can cause skeletal muscle atrophy, usually accompanied by inflammation,
mitochondrial dysfunction, apoptosis, decreased protein synthesis, and enhanced …

Many pathological states characterized by muscle atrophy (eg, sepsis, cachexia, starvation,
metabolic acidosis and severe insulinopenia) are associated with an increase in circulating …

The molecular mechanisms underlying skeletal muscle maintenance involve interplay
between multiple signaling pathways. Under normal physiological conditions, a network of …

The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …

Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced
protein synthesis/accelerated protein degradation. Various conditions, such as denervation …

Skeletal muscle atrophy occurs in many chronic diseases and disuse conditions. Its severity
reduces patient recovery, independence and quality of life. The discovery of two muscle …

Insulin resistance is a fundamental pathogenic factor present in various metabolic disorders
including obesity and type 2 diabetes. Although skeletal muscle accounts for 70–90% of …

Although it is believed that neural activation can affect immune responses, very little is
known about the neuroimmune interactions involved, especially the regulators of immune …

Glucocorticoids (GCs) exert key metabolic influences on skeletal muscle. GCs increase
protein degradation and decrease protein synthesis. The released amino acids are …