Epithelial and endothelial cell-cell contacts are established and maintained by several
intercellular junctional complexes. These structurally and biochemically differentiated …

The mechanisms that regulate the spatial sorting of nonmuscle myosins-2 (NM2) isoforms
and couple them mechanically to the plasma membrane are unclear. Here we show that the …

Introduction: Researchers have investigated the potential role of intestinal permeability in
Crohn's disease pathogenesis. Intestinal permeability is usually mediated by cytoskeleton …

Transmembrane proteins of adherens and tight junctions are known targets for viruses and
bacterial toxins. The coronavirus receptor ACE2 has been localized at the apical surface of …

Paracingulin (CGNL1) is recruited to tight junctions (TJs) by ZO-1 and to adherens junctions
(AJs) by PLEKHA7. PLEKHA7 has been reported to bind to the microtubule minus-end …

Zonula occludens-1 (ZO-1), the major scaffolding protein of tight junctions (TJs), recruits the
cytoskeleton-associated proteins cingulin (CGN) and paracingulin (CGNL1) to TJs by …

Copper homeostasis is crucial for cellular physiology and development, and its
dysregulation leads to disease. The Menkes ATPase ATP7A plays a key role in copper …

We previously identified PLEKHA7 and other junctional proteins as host factors mediating
death by S. aureus α-toxin, but the mechanism through which junctions promote toxicity was …

Cingulin (CGN) and paracingulin (CGNL1) are cytoplasmic proteins of tight junctions (TJs),
where they play a role in tethering ZO-1 to the actomyosin and microtubule cytoskeletons …

PLEKHA5, PLEKHA6, and PLEKHA7 (WW-PLEKHAs) are members of the PLEKHA family of
proteins that interact with PDZD11 through their tandem WW domains. WW-PLEKHAs …