Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

Fungal species have dynamic genomes and often exhibit genomic plasticity in response to
stress. This genome plasticity often comes with phenotypic consequences that affect fitness …

Copy number variants (CNVs), duplications and deletions of genomic sequences, contribute
to evolutionary adaptation but can also confer deleterious effects and cause disease …

Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene
functions and allows the generalizability of laboratory findings to be assessed. One notable …

Aneuploidy, an imbalance in chromosome copy numbers, causes genetic disorders, and
drives cancer progression, drug tolerance, and antimicrobial resistance. While aneuploidy …

Individuals carrying an aberrant number of chromosomes can vary widely in their expression
of aneuploidy phenotypes. A major unanswered question is the degree to which an …

Under normal conditions, to achieve optimal spermatogenesis, the temperature of the testes
should be 2–6° C lower than body temperature. Cryptorchidism is one of the common …

The yeast S. cerevisiae is a unique genetic object for which a wide range of relatively
simple, inexpensive, and non-time-consuming methods have been developed that allow the …

Mutations in DNA can be limited to one or a few nucleotides, or encompass larger deletions,
insertions, duplications, inversions and translocations that span long stretches of DNA or …

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts,
proteins, and metabolites, often resulting in detrimental effects for the organism. The …