Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell
growth factor essential for the proliferation of T cells and the generation of effector and …

Making sense of rapidly evolving evidence on genetic associations is crucial to making
genuine advances in human genomics and the eventual integration of this information in the …

The discovery of the association between HLA in the major histocompatibility complex
(MHC) on chromosome 6p21 with type 1 diabetes, but not with type 2 diabetes, suggested …

OBJECTIVE In humans, multiple genes in the interleukin (IL)-2/IL-2 receptor (IL-2R) pathway
are associated with type 1 diabetes. However, no link between IL-2 responsiveness and …

Arguably, the main challenge for contemporary genetics is to understand the function of
every gene in a mammalian genome. The mouse has emerged as a model for this task …

Abstract Long non-coding RNAs (LncRNAs) are a class of endogenous RNA molecules,
which have a transcribing length of over 200 nt, lack a complete functional open reading …

According to the current WHO classification of cardiomyopathies, myocarditis is an
inflammatory disease of the myocardium and is diagnosed by endomyocardial biopsy using …

Epistasis could be an important source of risk for disease. How interacting loci might be
discovered is an open question for genome‐wide association studies (GWAS). Most …

Genetic investigations often involve the testing of vast numbers of related hypotheses
simultaneously. To control the overall error rate, a substantial penalty is required, making it …

Context/Objectives: It is known that different autoimmune diseases often share the same
susceptibility genes. In this study we aimed to investigate if loci found associated with …