The two sides of chromosomal instability: drivers and brakes in cancer
R Hosea, S Hillary, S Naqvi, S Wu… - Signal Transduction and …, 2024 - nature.com
Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …
[HTML][HTML] PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response
W Yue, X Li, X Zhan, L Wang, J Ma, M Bi, Q Wang… - Ebiomedicine, 2024 - thelancet.com
Background Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising
chemotherapeutic drugs primarily against BRCA1/2-associated tumours, known as synthetic …
chemotherapeutic drugs primarily against BRCA1/2-associated tumours, known as synthetic …
Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T-Cell Immunity against Cancer
J Mowat, R Carretero, G Leder… - Journal of Medicinal …, 2024 - ACS Publications
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) is a serine/threonine
kinase that acts as an immune checkpoint downstream of T-cell receptor stimulation …
kinase that acts as an immune checkpoint downstream of T-cell receptor stimulation …
Effect of Emi1 gene silencing on the proliferation and invasion of human breast cancer cells
Y Kuang, S Huang, S Tang, Z Zhuo… - BMC Molecular and Cell …, 2023 - Springer
Breast cancer is the most common malignant tumour in women. The early silk-splitting
inhibitor protein 1 Emi1 is responsible for mediating ubiquitin protein degradation. The …
inhibitor protein 1 Emi1 is responsible for mediating ubiquitin protein degradation. The …
Cancer Cell Migration Targeted Therapies
BU KAHYA, ASYAR SAĞLAM - Turkiye Klinikleri Medical …, 2024 - turkiyeklinikleri.com
Metastasis is one of the leading causes of cancer-related mortality and inhibition of cancer
cell migration is a valuable therapeutic target. Several processes, including mesenchymal …
cell migration is a valuable therapeutic target. Several processes, including mesenchymal …
Exploiting DNA Repair Deficiencies in Cancer to Develop and Characterize Novel Therapeutics
S Paradkar - 2023 - search.proquest.com
Genomic instability is one of the hallmarks of cancer, which underlies cancer development
and progression. This DNA repair vulnerability presents cancer researchers with a …
and progression. This DNA repair vulnerability presents cancer researchers with a …