As the standard treatments for cancer, chemotherapy and radiotherapy have been widely
applied to clinical practice worldwide. However, the resistance to cancer therapies is a major …

Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by
facilitating tumor cell invasion and dissemination to distant organs. Recent evidences …

The predominant way in which conventional chemotherapy kills rapidly proliferating cancer
cells is the induction of DNA damage. However, chemoresistance remains the main obstacle …

Molecular signaling pathways involved in cancer have been intensively studied due to their
crucial role in cancer cell growth and dissemination. Among them, zinc finger E-box binding …

Radiotherapy remains one of the major treatments for non-small cell lung cancer (NSCLC)
patients; whereas intrinsic or acquired radioresistance limits its efficacy. Nevertheless, most …

Cancer patients with different stages can benefit from radiotherapy, but there are still limited
due to inherent or acquired radioresistance. The epithelial-mesenchymal transition (EMT) is …

Prostate cancer (PC) is a very important kind of male malignancies. When PC evolves into a
stage of hormone resistance or metastasis, the fatality rate is very high. Currently …

Radiotherapy is a cancer treatment that applies high doses of ionizing radiation to induce
cell death, mainly by triggering DNA double-strand breaks. The outcome of radiotherapy …

The susceptibility of cancer cells to different types of treatments can be restricted by intrinsic
and acquired therapeutic resistance, leading to the failure of cancer regression and …

One of the main problems with the treatment of metastatic prostate cancer is that, despite an
initial positive response, the majority of patients develop resistance and progress. In …