Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

Background Acromegaly is a rare and underdiagnosed disorder caused, in more than 95%
of cases, by a growth hormone (GH)-secreting pituitary adenoma. The GH hypersecretion …

Objective: To clarify the selection of medical therapy following transsphenoidal surgery in
patients with acromegaly, based on growth hormone (GH)/insulin-like growth factor 1 (IGF-1) …

Comorbidities related to the cardiovascular system are one of the most prevalent in patients
with acromegaly, and contribute to an increased risk of morbidity and all-cause mortality …

Obesity is an excessive accumulation or expansion of adipose tissue (AT) due to an
increase in either the size and/or number of its characteristic cell type, the adipocyte. As one …

Introduction In acromegaly, chronic exposure to impaired GH and IGF-I levels leads to the
development of typical acromegaly symptoms, and multiple systemic complications as …

Standard treatment for acromegaly focuses on the achievement of target absolute levels of
growth hormone (GH) and insulin-like growth factor (IGF-I). The appropriateness of these …

Pasireotide, a multireceptor-targeted somatostatin analogue with highest affinity for
somatostatin receptor subtype (SST) 5, has demonstrated superior efficacy over the SST2 …

Acromegaly is an uncommon, chronic disease, characterized by hypersecretion of a pituitary
growth hormone by somatotroph adenomas, along with increased levels of insulin-like …

Acromegaly is a rare and severe disease caused by an increased and autonomous
secretion of growth hormone (GH), thus resulting in high circulating levels of insulin-like …