The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …

Mutations in the promoter of human telomerase reverse transcriptase (hTERT) result in
hyperactivation of hTERT. Notably, all mutations are G> A transitions, frequently found in a …

Background Telomerase is a ribonucleoprotein complex consisting of a catalytic component
telomerase reverse transcriptase (TERT), internal RNA template and other co‐factors, and …

Background Biomarkers acquired from blood samples are easy to obtain and cost-effective,
have attracted considerable interest, and have been widely investigated. Inflammation plays …

The telomerase reverse transcriptase (TERT) is overexpressed and associated with poor
prognosis in papillary thyroid cancer (PTC), the most common subtype of thyroid cancer. The …

Aberrant activation of telomerase in human cancer is achieved by various alterations within
the TERT promoter, including cancer-specific DNA hypermethylation of the TERT …

Telomerase, an RNA-dependent DNA polymerase synthesizing telomeric TTAGGG
sequences, is primarily silent in normal human urothelial cells (NHUCs), but widely activated …

Telomerase reverse transcriptase (TERT/hTERT) serves as the pivotal catalytic subunit of
telomerase, a crucial enzyme responsible for telomere maintenance and human genome …

Telomere shortening at chromosomal ends due to the constraints of the DNA replication
process acts as a tumor suppressor by restricting the replicative potential in primary cells …

Cutaneous T‐cell lymphomas (CTCLs) are telomerase‐positive tumors expressing hTERT,
although neither gene rearrangement/amplification nor promoter hotspot mutations could …