Autophagy is a highly conserved and fundamental cellular process to maintain cellular
homeostasis through recycling of defective organelles or proteins. In a response to …

The sharp increase in infections associated with multidrug-resistant (MDR) bacterial
pathogens that have seriously compromised traditional chemotherapeutics is becoming a …

Septins are cytoskeletal proteins that assemble into hetero-oligomeric complexes and sense
micron-scale membrane curvature. During infection with Shigella flexneri, an invasive …

Investigation of cytoskeleton during bacterial infection has significantly contributed to both
cell and infection biology. Bacterial pathogens Listeria monocytogenes and Shigella flexneri …

Louis Pasteur made seminal discoveries in microbiology, immunology and vaccinology that
transformed clinical science and saved millions of lives. Since the 19th century, our ability to …

Septins are widely recognized as a component of the cytoskeleton that is essential for cell
division, and new work has shown that septins can recognise cell shape by assembling into …

Although many prospective antibiotic targets are known, bacterial infections and resistance
to antibiotics remain a threat to public health partly because the druggable potentials of most …

Abstract Shigella flexneri (S. flexneri), the causative agent of bacillary dysentery, uses an
effector‐mediated strategy to hijack host cells and cause disease. To propagate and spread …

Bacterial pathogens cause disease by subverting the structure and function of their target
host cells. Several foodborne agents such as Listeria monocytogenes (L. monocytogenes) …

The type VI secretion system (T6SS) injects effector proteins into neighboring bacteria and
host cells. Effector translocation is driven by contraction of a tubular sheath in the cytoplasm …