Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1
with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression …

Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …

It is clear from large clinical studies that selected chemokine receptors are often up-
regulated in a large number of common human cancers, including those of the breast, lung …

BACKGROUND Initially identified as suppressors of metastasis in various types of cancer,
kisspeptins are a family of neuropeptides that are key regulators of the mammalian …

Cancer of unknown primary site (CUP) ranks as the fourth most common cause of cancer
deaths and represents both a diagnostic and a management challenge. In CUP, the …

Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth
factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need …

Background The KISS1 protein suppresses metastasis of several tumor models without
blocking orthotopic tumor growth, but the mechanism remains elusive. For its role in human …

Kisspeptins, a family of peptide products derived from the KiSS-1 gene, activate their
cognate receptor GPR54 in various target tissues to exert disparate functions, including …