Abnormal Ca2+ channel physiology, expression levels, and hypersensitivity to heat have
been implicated in several pain states following treatment with chemotherapeutic agents. As …

Diabetes mellitus, a debilitating chronic disease, affects~ 100 million people. Peripheral
neuropathy is one of the most common early complications of diabetes in~ 66% of these …

Epilepsy has 2-3% incidence worldwide. However, present antiepileptic drugs provide only
partial control of seizures. Calcium ion accumulation in hippocampal neurons has long been …

Pain is a complex physiological process that includes many components. Growing evidence
supports the idea that oxidative stress and Ca2+ signaling pathways participate in pain …

Abstract Background Cinnamomum cassia (L.) J. Presl (Cinnamon) was known as a kind of
hot herb, improved circulation and warmed the body. However, the active components and …

Menthol is a naturally occurring monoterpene alcohol possessing remarkable biological
properties including antipruritic, analgesic, antiseptic, anti-inflammatory and cooling effects …

ABSTRACT Transient Receptor Potential Melastatin-like 7 (TRPM7), Transient Receptor
Potential Melastatin-like 8 (TRPM8) and Transient Receptor Potential Vanilloid-like 1 …

The transient receptor potential channel (TRP) channels are expressed in neuronal tissues
and involved in neurological diseases such as pain, epilepsy, neuronal apoptosis, and …

The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [145, 915]),
whose founder member is the Drosophila Trp channel, exists in mammals as six families; …

It is well known that Ca 2+ influx through cation channels induces peripheral pain in dorsal
root ganglion (DRG) neurons. Melastatin-like transient receptor potential 2 (TRPM2) channel …