Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

Biological species, including reactive oxygen species (ROS), reactive sulfur species (RSS),
reactive nitrogen species (RNS), F−, Pd2+, Cu2+, Hg2+, and others, are crucial for the …

Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows
broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN …

Abstract Phosphatidylinositol (4, 5) bisphosphate (PI (4, 5) P2) has become a major focus in
biochemistry, cell biology and physiology owing to its diverse functions at the plasma …

Viruses rely on the reprogramming of cellular processes to enable efficient viral replication;
this often requires subcompartmentalization within the host cell. Liquid–liquid phase …

Viruses are highly dependent on the host they infect. Their dependence triggers processes
of virus–host co-adaptation, enabling viruses to explore host resources whilst escaping …

The endoplasmic reticulum (ER) is the site of synthesis of secretory and membrane proteins
and contacts every organelle of the cell, exchanging lipids and metabolites in a highly …

HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered
membrane microdomains. The size and stability of membrane microdomains is regulated by …