[HTML][HTML] Circular RNAs: Characterization, cellular roles, and applications
CX Liu, LL Chen - Cell, 2022 - cell.com
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …
Recent technological advances have in part overcome problems with their circular …
Biogenesis and regulatory roles of circular RNAs
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
Circular RNA: metabolism, functions and interactions with proteins
WY Zhou, ZR Cai, J Liu, DS Wang, HQ Ju, RH Xu - Molecular cancer, 2020 - Springer
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …
that are ubiquitous across species ranging from viruses to mammals. Important advances …
RNA in cancer
GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
[HTML][HTML] Review on circular RNAs and new insights into their roles in cancer
X Tang, H Ren, M Guo, J Qian, Y Yang, C Gu - … and structural biotechnology …, 2021 - Elsevier
Circular RNAs (circRNAs) are a very interesting class of conserved single-stranded RNA
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …
molecules derived from exonic or intronic sequences by precursor mRNA back-splicing …
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition
L Muniz, E Nicolas, D Trouche - The EMBO journal, 2021 - embopress.org
Abstract RNA polymerase II (RNA Pol II) speed or elongation rate, ie, the number of
nucleotides synthesized per unit of time, is a major determinant of transcriptome …
nucleotides synthesized per unit of time, is a major determinant of transcriptome …
[HTML][HTML] Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer
J Chen, Y Wu, X Luo, D Jin, W Zhou, Z Ju, D Wang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Tumor metastasis of colorectal cancer (CRC) is the main cause of death in
most patients and the major difficulty in comprehensive CRC treatment. Circular RNAs …
most patients and the major difficulty in comprehensive CRC treatment. Circular RNAs …
Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer
Y Chen, Y Lin, Y Shu, J He, W Gao - Molecular cancer, 2020 - Springer
As a critical internal RNA modification in higher eukaryotes, N 6-methyladenosine (m 6 A)
has become the hotspot of epigenetics research in recent years. Extensive studies on …
has become the hotspot of epigenetics research in recent years. Extensive studies on …
CRISPR/Cas13 effectors have differing extents of off-target effects that limit their utility in eukaryotic cells
CRISPR/Cas13 effectors have garnered increasing attention as easily customizable tools for
detecting and depleting RNAs of interest. Near perfect complementarity between a target …
detecting and depleting RNAs of interest. Near perfect complementarity between a target …
[HTML][HTML] Exosomes in atherosclerosis: performers, bystanders, biomarkers, and therapeutic targets
C Wang, Z Li, Y Liu, L Yuan - Theranostics, 2021 - ncbi.nlm.nih.gov
Exosomes are nanosized lipid vesicles originating from the endosomal system that carry
many macromolecules from their parental cells and play important roles in intercellular …
many macromolecules from their parental cells and play important roles in intercellular …