Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Simple Summary Liver metastasis remains the major contributor in colorectal cancer-related
death. It has become clear that the unique immune features of liver microenvironment take …

Hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality but lacks
effective treatments thus far. Although the emergence of immune checkpoint inhibitors in …

Objective Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive
cellular therapy have had limited success in patients with microsatellite stable colorectal …

Galectins are galactoside-binding proteins, exerting numerous functions inside and outside
the cell, particularly conferring adaptation to stress factors. For most of them, aberrant …

Patient derived organoids closely resemble the biology of tissues and tumors. They are
enabling ex vivo modeling of human diseases and dissecting key features of tumor biology …

The basic idea behind the use of 3-dimensional (3D) tools in biomedical research is the
assumption that the structures under study will perform at the best in vitro if cultivated in an …

The impact of systemic therapy on the tumor microenvironment has been difficult to study in
human solid tumors. Our protocol describes steps for establishing slice cultures to …

The tumor microenvironment (TME) is critical for tumor growth and metastasis. The TME
contains cancer-associated cells, tumor matrix, and tumor secretory factors. The fabrication …

Glucose oxidase (GOx)-mediated starvation therapy holds great promise in cancer
treatment. However, the worse hypoxia conditions result into low therapeutic efficiency, and …