Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

H Calkins, G Hindricks, R Cappato, YH Kim… - Ep …, 2018 - academic.oup.com
AFL atrial flutter AH arterial hypertension ANS autonomic nervous system APD action
potential duration ARREST-AF Aggressive Risk Factor Reduction Study for Atrial Fibrillation …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

Calcium signaling and cardiac arrhythmias

AP Landstrom, D Dobrev, XHT Wehrens - Circulation research, 2017 - Am Heart Assoc
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT

IC Van Gelder, JS Healey, HJGM Crijns… - European heart …, 2017 - academic.oup.com
Background ASSERT demonstrated that subclinical atrial fibrillation (SCAF) is common in
pacemaker patients without prior AF and is associated with increased risk of ischemic stroke …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias

L Scott Jr, AC Fender, A Saljic, L Li… - Cardiovascular …, 2021 - academic.oup.com
Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with
enhanced inflammatory response. However, whether inflammatory signaling is causally …

The structural basis of ryanodine receptor ion channel function

G Meissner - Journal of General Physiology, 2017 - rupress.org
Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …

Animal models of atrial fibrillation

D Schüttler, A Bapat, S Kääb, K Lee, P Tomsits… - Circulation …, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in humans and
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …