Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …
and mortality. There have been significant management advances over the past 2 decades …
2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
AFL atrial flutter AH arterial hypertension ANS autonomic nervous system APD action
potential duration ARREST-AF Aggressive Risk Factor Reduction Study for Atrial Fibrillation …
potential duration ARREST-AF Aggressive Risk Factor Reduction Study for Atrial Fibrillation …
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
Calcium signaling and cardiac arrhythmias
There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …
Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT
IC Van Gelder, JS Healey, HJGM Crijns… - European heart …, 2017 - academic.oup.com
Background ASSERT demonstrated that subclinical atrial fibrillation (SCAF) is common in
pacemaker patients without prior AF and is associated with increased risk of ischemic stroke …
pacemaker patients without prior AF and is associated with increased risk of ischemic stroke …
Atrial remodeling and atrial fibrillation: recent advances and translational perspectives
S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …
complications are responsible for important population morbidity and mortality. Presently …
Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias
Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with
enhanced inflammatory response. However, whether inflammatory signaling is causally …
enhanced inflammatory response. However, whether inflammatory signaling is causally …
The structural basis of ryanodine receptor ion channel function
G Meissner - Journal of General Physiology, 2017 - rupress.org
Large-conductance Ca2+ release channels known as ryanodine receptors (RyRs) mediate
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …
the release of Ca2+ from an intracellular membrane compartment, the endo/sarcoplasmic …
Animal models of atrial fibrillation
D Schüttler, A Bapat, S Kääb, K Lee, P Tomsits… - Circulation …, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in humans and
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …
is a significant source of morbidity and mortality. Despite its prevalence, our mechanistic …