Emerging concepts and technologies in vaccine development
Despite the success of vaccination to greatly mitigate or eliminate threat of diseases caused
by pathogens, there are still known diseases and emerging pathogens for which the …
by pathogens, there are still known diseases and emerging pathogens for which the …
Molecular dynamics, monte carlo simulations, and langevin dynamics: a computational review
Macromolecular structures, such as neuraminidases, hemagglutinins, and monoclonal
antibodies, are not rigid entities. Rather, they are characterised by their flexibility, which is …
antibodies, are not rigid entities. Rather, they are characterised by their flexibility, which is …
Computational Methods in Immunology and Vaccinology: Design and Development of Antibodies and Immunogens
The design of new biomolecules able to harness immune mechanisms for the treatment of
diseases is a prime challenge for computational and simulative approaches. For instance, in …
diseases is a prime challenge for computational and simulative approaches. For instance, in …
Vaccine development: Current trends and technologies
Despite the effectiveness of vaccination in reducing or eradicating diseases caused by
pathogens, there remain certain diseases and emerging infections for which developing …
pathogens, there remain certain diseases and emerging infections for which developing …
Structural and computational biology in the design of immunogenic vaccine antigens
L Liljeroos, E Malito, I Ferlenghi… - Journal of immunology …, 2015 - Wiley Online Library
Vaccination is historically one of the most important medical interventions for the prevention
of infectious disease. Previously, vaccines were typically made of rather crude mixtures of …
of infectious disease. Previously, vaccines were typically made of rather crude mixtures of …
Chemical perturbation of oncogenic protein folding: from the prediction of locally unstable structures to the design of disruptors of Hsp90–client interactions
A Paladino, MR Woodford, SJ Backe… - … A European Journal, 2020 - Wiley Online Library
Protein folding quality control in cells requires the activity of a class of proteins known as
molecular chaperones. Heat shock protein‐90 (Hsp90), a multidomain ATP driven molecular …
molecular chaperones. Heat shock protein‐90 (Hsp90), a multidomain ATP driven molecular …
The answer lies in the energy: how simple atomistic molecular dynamics simulations may hold the key to epitope prediction on the fully glycosylated SARS-CoV-2 …
SA Serapian, F Marchetti, A Triveri… - The Journal of …, 2020 - ACS Publications
SARS-CoV-2 is a health threat with dire socioeconomical consequences. As the crucial
mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention …
mediator of infection, the viral glycosylated spike protein (S) has attracted the most attention …
Peptides for immunological purposes: design, strategies and applications
The development of new vaccines remains an attractive goal for disease prevention and
therapy, in combination or alternative to drug-based treatment. In parallel, a growing …
therapy, in combination or alternative to drug-based treatment. In parallel, a growing …
Protein microarray technology: how far off is routine diagnostics?
The nature of protein microarray platforms is favorable for multiplexing, leading to the
development of tools for personalised medicine and highly precise diagnostics. However, to …
development of tools for personalised medicine and highly precise diagnostics. However, to …
Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology
LJ Gourlay, C Peri, M Ferrer-Navarro… - Chemistry & biology, 2013 - cell.com
We solved the crystal structure of Burkholderia pseudomallei acute phase antigen
BPSL2765 in the context of a structural vaccinology study, in the area of melioidosis vaccine …
BPSL2765 in the context of a structural vaccinology study, in the area of melioidosis vaccine …