Biofilms are assemblages of microorganisms attached to each other, or to a surface, and
encased in a protective, self-produced matrix. Such associations are now recognized as the …

Microbial biofilms, which are elaborate and highly resistant microbial aggregates formed on
surfaces or medical devices, cause two-thirds of infections and constitute a serious threat to …

The search for new antimicrobials is imperative due to the emergent resistance of new
microorganism strains. In this context, revisiting known classes like 8-hydroxyquinolines …

Current studies of human gut microbiome usually do not consider the special functional role
of transient microbiota, although some of its members remain in the host for a long time and …

Hydroxyquinoline (8HQ) compounds have been reported to possess diverse bioactivities. In
recent years, drug repositioning has gained considerable attention in drug discovery and …

Iron is essential for multiple bacterial processes and is thus required for host colonization
and infection. The antimicrobial activity of multiple iron chelators and gallium-based …

Metal complexes with organelle specificity and potent but selective cytotoxicity are highly
desirable. In this work, we report the synthesis, characterization and cytotoxicity of six novel …

Background Nitroxoline, a hydroxychinoline derivate, has been used for many years to treat
urinary tract infections (UTI). Many uncontrolled, but only few controlled clinical studies have …

In the era of escalating antimicrobial resistance, the need for antibacterial drugs with novel
or improved modes of action (MOAs) is a health concern of utmost importance. Adding or …

Purpose Fork head box M1 (FoxM1) is an oncogenic transcription factor frequently elevated
in numerous cancers, including cholangiocarcinoma (CCA). A growing body of evidence …