Post-translational modifications (PTMs) occur on nearly all proteins. Many domains within
proteins are modified on multiple amino acid sidechains by diverse enzymes to create a …

Scaffold proteins influence cellular signalling by binding to multiple signalling enzymes,
receptors or ion channels. Although normally devoid of catalytic activity, they have a big …

Protein S-acylation (palmitoylation), a reversible post-translational modification, is critically
involved in regulating protein subcellular localization, activity, stability, and multimeric …

" As will be seen, there is not much missing here. I thought that the sections were well
balanced, with rarely too much or too little on a given topic... This is a text to be welcomed by …

In the vertebrate immune system, each B-lymphocyte expresses a surface IgM-class B cell
receptor (BCR). When cross-linked by antigen or anti-IgM antibody, the BCR accumulates …

Mass spectrometry has served as a major tool for the discipline of proteomics to catalogue
proteins in an unprecedented scale. With chemical and metabolic techniques for stable …

Akt is a critical protein for cell survival and known to interact with various proteins. However,
Akt binding partners that modulate or regulate Akt activation have not been fully elucidated …

Synapse dysfunction is an integral feature of Alzheimer's disease (AD) pathophysiology. In
fact, prodromal manifestation of structural and functional deficits in synapses much prior to …

Mapping protein interactions and their dynamics is crucial to defining physiologic states,
building effective models for understanding cell function, and to allow more effective …

Label‐based quantitative mass spectrometry analysis of affinity purified complexes, with its
built‐in negative controls and relative ease of use, is an increasingly popular choice for …