RNA chaperones, RNA annealers and RNA helicases
L Rajkowitsch, D Chen, S Stampfl, K Semrad… - RNA biology, 2007 - Taylor & Francis
RNA molecules face difficulties when folding into their native structures. In the cell, proteins
can assist RNAs in reaching their functionally active states by binding and stabilizing a …
can assist RNAs in reaching their functionally active states by binding and stabilizing a …
Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription
JG Levin, M Mitra, A Mascarenhas, K Musier-Forsyth - RNA biology, 2010 - Taylor & Francis
The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic
acid structures so that the most thermodynamically stable conformations are formed. This …
acid structures so that the most thermodynamically stable conformations are formed. This …
Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3G
Abstract APOBEC3G (A3G), a host protein that inhibits HIV-1 reverse transcription and
replication in the absence of Vif, displays cytidine deaminase and single-stranded (ss) …
replication in the absence of Vif, displays cytidine deaminase and single-stranded (ss) …
Biophysical characterization of DNA binding from single molecule force measurements
KR Chaurasiya, T Paramanathan, MJ McCauley… - Physics of life …, 2010 - Elsevier
Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …
Proteins that chaperone RNA regulation
SA Woodson, S Panja… - Microbiology …, 2018 - Am Soc Microbiol
ABSTRACT RNA-binding proteins chaperone the biological functions of noncoding RNA by
reducing RNA misfolding, improving matchmaking between regulatory RNA and targets, and …
reducing RNA misfolding, improving matchmaking between regulatory RNA and targets, and …
Nucleic acid chaperone properties of ORF1p from the non-LTR retrotransposon, LINE-1
SL Martin - RNA biology, 2010 - Taylor & Francis
Long interspersed element-1 (LINE-1, or L1) is a non-long terminal repeat (LTR)
retrotransposon that has amplified to hundreds of thousands of copies in mammalian …
retrotransposon that has amplified to hundreds of thousands of copies in mammalian …
Taming free energy landscapes with RNA chaperones
SA Woodson - RNA biology, 2010 - Taylor & Francis
Many non-coding RNAs fold into complex three-dimensional structures, yet the self-
assembly of RNA structure is hampered by mispairing, weak tertiary interactions …
assembly of RNA structure is hampered by mispairing, weak tertiary interactions …
HIV-1 Pr55Gag binds genomic and spliced RNAs with different affinity and stoichiometry
S Bernacchi, EW Abd El-Wahab, N Dubois, M Hijnen… - RNA biology, 2017 - Taylor & Francis
ABSTRACT The HIV-1 Pr55Gag precursor specifically selects genomic RNA (gRNA) from a
large variety of cellular and spliced viral RNAs (svRNAs), however the molecular …
large variety of cellular and spliced viral RNAs (svRNAs), however the molecular …
NCp7: Targeting a multitasking protein for next-generation anti-HIV drug development part 1: Covalent inhibitors
Highlights•NCp7 plays several roles in the viral life cycle.•Covalent NCp7 inhibitors are able
to extrude the zinc from the protein.•The SAR of covalent NCp7 inhibitors is discussed.•The …
to extrude the zinc from the protein.•The SAR of covalent NCp7 inhibitors is discussed.•The …
Nucleocapsid protein: a desirable target for future therapies against HIV-1
HIV reverse transcription and nucleocapsid. After the capsid has entered the cell, reverse
transcriptase (A) creates a DNA copy (green) of the HIV RNA genome (yellow), using a …
transcriptase (A) creates a DNA copy (green) of the HIV RNA genome (yellow), using a …