RNA molecules face difficulties when folding into their native structures. In the cell, proteins
can assist RNAs in reaching their functionally active states by binding and stabilizing a …

The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic
acid structures so that the most thermodynamically stable conformations are formed. This …

Abstract APOBEC3G (A3G), a host protein that inhibits HIV-1 reverse transcription and
replication in the absence of Vif, displays cytidine deaminase and single-stranded (ss) …

Single molecule force spectroscopy is a powerful method that uses the mechanical
properties of DNA to explore DNA interactions. Here we describe how DNA stretching …

ABSTRACT RNA-binding proteins chaperone the biological functions of noncoding RNA by
reducing RNA misfolding, improving matchmaking between regulatory RNA and targets, and …

Long interspersed element-1 (LINE-1, or L1) is a non-long terminal repeat (LTR)
retrotransposon that has amplified to hundreds of thousands of copies in mammalian …

Many non-coding RNAs fold into complex three-dimensional structures, yet the self-
assembly of RNA structure is hampered by mispairing, weak tertiary interactions …

ABSTRACT The HIV-1 Pr55Gag precursor specifically selects genomic RNA (gRNA) from a
large variety of cellular and spliced viral RNAs (svRNAs), however the molecular …

Highlights•NCp7 plays several roles in the viral life cycle.•Covalent NCp7 inhibitors are able
to extrude the zinc from the protein.•The SAR of covalent NCp7 inhibitors is discussed.•The …

HIV reverse transcription and nucleocapsid. After the capsid has entered the cell, reverse
transcriptase (A) creates a DNA copy (green) of the HIV RNA genome (yellow), using a …