The emerging role of Raman spectroscopy as an omics approach for metabolic profiling and biomarker detection toward precision medicine

G Cutshaw, S Uthaman, N Hassan… - Chemical …, 2023 - ACS Publications
Omics technologies have rapidly evolved with the unprecedented potential to shape
precision medicine. Novel omics approaches are imperative toallow rapid and accurate data …

Powering smart contact lenses for continuous health monitoring: Recent advancements and future challenges

H Mirzajani, F Mirlou, E Istif, R Singh, L Beker - Biosensors and …, 2022 - Elsevier
As the tear is noninvasively and continuously available, it has been turned into a convenient
biological interface as a wearable medical device for out-of-hospital and self-monitoring …

Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients

M Shahidatul-Adha, E Zunaina, MN Aini-Amalina - Scientific reports, 2022 - nature.com
Age-related macular degeneration (AMD) is an important cause of irreversible central
blindness worldwide. Clinical manifestations range from asymptomatic in early and …

Protein profile analysis of tear fluid with hyphenated HPLC-UV LED-induced fluorescence detection for the diagnosis of dry eye syndrome

SS Adigal, SV Bhandary, N Hegde, VR Nidheesh… - RSC …, 2023 - pubs.rsc.org
Tear fluid contains organic and inorganic constituents, variations in their relative
concentrations could provide valuable information and can be useful for the detection of …

[HTML][HTML] Protein profile pattern analysis: A multifarious, in vitro diagnosis technique for universal screening

AK Barik, C Mathew, PM Sanoop, RV John… - … of Chromatography B, 2024 - Elsevier
Universal health care is attracting increased attention nowadays, because of the large
increase in population all over the world, and a similar increase in life expectancy, leading to …

Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients

J Brunmair, A Bileck, D Schmidl, G Hagn… - EPMA Journal, 2022 - Springer
Background/aims Concerning healthcare approaches, a paradigm change from reactive
medicine to predictive approaches, targeted prevention, and personalisation of medical …

Shedding Valuable Tears: Tear Fluid as a Promising Source of Disease Biomarkers

IS Vavilina, AA Shpak, TA Druzhkova, AB Guekht… - Neurochemical …, 2023 - Springer
The simplicity of collecting and evaluating tear fluid (TF) can potentially provide a convenient
non-invasive diagnostic tool that easily fits into a personalized approach to medicine based …

Unveiling brain disorders using liquid biopsy and Raman spectroscopy

JC Ranasinghe, Z Wang, S Huang - Nanoscale, 2024 - pubs.rsc.org
Brain disorders, including neurodegenerative diseases (NDs) and traumatic brain injury
(TBI), present significant challenges in early diagnosis and intervention. Conventional …

Development, Optimization, and Clinical Relevance of Lactoferrin Delivery Systems: A Focus on Ocular Delivery

E Ponzini, G Astolfi, R Grandori, S Tavazzi, P Versura - Pharmaceutics, 2024 - mdpi.com
Lactoferrin (Lf), a multifunctional protein found abundantly in secretions, including tears,
plays a crucial role in ocular health through its antimicrobial, immunoregulatory, anti …

Al-doped ZnO Nanostars for Electrochemical miRNA-21 Biosensors

B Sun, H Tang, G Gao, Y Qian, Q Shen… - Journal of The …, 2024 - iopscience.iop.org
The accurate and cost-effective detection of miRNAs, which are strongly associated with
numerous diseases and disorders, poses significant technical challenges due to their small …