The concept of a prion as an infectious self-propagating protein isoform was initially
proposed to explain certain mammalian diseases. It is now clear that yeast also has …

Prions are fascinating but often misunderstood protein aggregation phenomena. The
traditional association of the mammalian prion protein with disease has overshadowed a …

The accumulation of misfolded proteins is a common feature of many neurodegenerative
diseases. These observations suggest a potential link between these disorders and protein …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by selective loss of motor neurons with inclusions frequently containing the …

Yeast prion [PSI+] is a self-perpetuating amyloid of the translational termination factor
Sup35. Although [PSI+] propagation is modulated by heat shock proteins (Hsps), high …

Yeast prions are atypical genetic elements that are transmitted as heritable protein
conformations.[PSI+],[URE3], and [PIN+] are three well-studied prions in the budding yeast …

Amyloid appearance is a rare event that is promoted in the presence of other aggregated
proteins. These aggregates were thought to act by templating the formation of an assembly …

Human chaperone DnaJB6, an Hsp70 co-chaperone whose defects cause myopathies,
protects cells from polyglutamine toxicity and prevents purified polyglutamine and Aβ …

Background Chemical-genetic profiling of inhibitory compounds can lead to identification of
their modes of action. These profiles can help elucidate the complex interactions between …

The yeast [PSI+] prion, formed by the Sup35 (eRF3) protein, has multiple structural variants
differing in the strength of nonsense suppressor phenotype. Structure of [PSI+] and its …