[HTML][HTML] The role of thrombin in haemostasis
OM Al-Amer - Blood Coagulation & Fibrinolysis, 2022 - journals.lww.com
Thrombin is a multifunctional serine protease generated in injured cells. The generation of
thrombin in coagulation plays a central role in the functioning of haemostasis. The last …
thrombin in coagulation plays a central role in the functioning of haemostasis. The last …
Therapeutics targeting the fibrinolytic system
The function of the fibrinolytic system was first identified to dissolve fibrin to maintain
vascular patency. Connections between the fibrinolytic system and many other physiological …
vascular patency. Connections between the fibrinolytic system and many other physiological …
[HTML][HTML] Large-scale multi-omic analysis of COVID-19 severity
KA Overmyer, E Shishkova, IJ Miller, J Balnis… - Cell systems, 2021 - cell.com
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
[HTML][HTML] COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status
BACKGROUND Reprogramming of host metabolism supports viral pathogenesis by fueling
viral proliferation, by providing, for example, free amino acids and fatty acids as building …
viral proliferation, by providing, for example, free amino acids and fatty acids as building …
Fibrinolysis and inflammation in venous thrombus resolution
S Mukhopadhyay, TA Johnson, N Duru… - Frontiers in …, 2019 - frontiersin.org
Clinical observations and accumulating laboratory evidence support a complex interplay
between coagulation, inflammation, innate immunity and fibrinolysis in venous …
between coagulation, inflammation, innate immunity and fibrinolysis in venous …
Genetic insights into therapeutic targets for aortic aneurysms: A Mendelian randomization study
Y Chen, X Xu, L Wang, K Li, Y Sun, L Xiao, J Dai… - …, 2022 - thelancet.com
Summary Background As aortic aneurysms (AAs) enlarge, they can become life-threatening
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …
if left undiagnosed or neglected. At present, there is a lack of radical treatments for …
[HTML][HTML] The multifaceted role of plasminogen in inflammation
A fine-tuned activation and deactivation of proteases and their inhibitors are involved in the
execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted …
execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted …
Recognition of plasminogen activator inhibitor type 1 as the primary regulator of fibrinolysis
The fibrinolytic system consists of a balance between rates of plasminogen activation and
fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three …
fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three …
[HTML][HTML] Blood clot contraction differentially modulates internal and external fibrinolysis
Essentials• Clot contraction influences the rate of fibrinolysis in vitro.• Internal fibrinolysis is
enhanced∼ 2‐fold in contracted vs. uncontracted blood clots.• External fibrinolysis is∼ 4 …
enhanced∼ 2‐fold in contracted vs. uncontracted blood clots.• External fibrinolysis is∼ 4 …
[HTML][HTML] Fibrinolysis: an illustrated review
In response to vessel injury (or other pathological conditions), the hemostatic process is
activated, resulting in a fibrous, cellular-rich structure commonly referred to as a blood clot …
activated, resulting in a fibrous, cellular-rich structure commonly referred to as a blood clot …