Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation

R Wu, R Xiong, Y Li, J Chen, R Yan - Journal of Autoimmunity, 2023 - Elsevier
Gut dysbiosis has been associated with inflammatory bowel disease (IBD), one of the most
common gastrointestinal diseases. The microbial communities play essential roles in host …

FODMAPs, inflammatory bowel disease and gut microbiota: updated overview on the current evidence

CD Simões, M Maganinho, AS Sousa - European journal of nutrition, 2022 - Springer
Purpose Based on the fermentable oligosaccharides, disaccharides, monosaccharides and
polyols (FODMAP) hypothesis, the low-FODMAP diet has been suggested as a potential …

Probiotics (Lactobacillus plantarum HNU082) supplementation relieves ulcerative colitis by affecting intestinal barrier functions, immunity-related gene expression, gut …

Y Wu, R Jha, A Li, H Liu, Z Zhang, C Zhang… - Microbiology …, 2022 - Am Soc Microbiol
Probiotics can effectively improve ulcerative colitis (UC), but the mechanism is still unclear.
Here, shotgun metagenome and transcriptome analyses were performed to explore the …

Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont

P Kuffa, JM Pickard, A Campbell, M Yamashita… - Cell Host & Microbe, 2023 - cell.com
Exclusive enteral nutrition (EEN) with fiber-free diets is an effective steroid-sparing treatment
to induce clinical remission in children with Crohn's disease (CD). However, the mechanism …

Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases

A Kumbhari, TNH Cheng, AN Ananthakrishnan… - Cell Host & Microbe, 2024 - cell.com
Gut bacteria are implicated in inflammatory bowel disease (IBD), but the strains driving these
associations are unknown. Large-scale studies of microbiome evolution could reveal the …

Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

S Nishijima, E Stankevic, O Aasmets, TSB Schmidt… - Cell, 2024 - cell.com
The microbiota in individual habitats differ in both relative composition and absolute
abundance. While sequencing approaches determine the relative abundances of taxa and …

Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization

KK Jang, T Heaney, M London, Y Ding, G Putzel… - Cell Host & Microbe, 2023 - cell.com
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of
the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also …

Genistein ameliorates inflammation and insulin resistance through mediation of gut microbiota composition in type 2 diabetic mice

R Yang, Q Jia, S Mehmood, S Ma, X Liu - European Journal of Nutrition, 2021 - Springer
Purpose Genistein (GEN) has been reported to have diverse biological activities, including
antioxidant, hypolipidemic, and antidiabetic effects. This study investigated whether the …

Linking human milk oligosaccharide metabolism and early life gut microbiota: Bifidobacteria and beyond

C Lordan, AK Roche, D Delsing, A Nauta… - Microbiology and …, 2024 - Am Soc Microbiol
Human milk oligosaccharides (HMOs) are complex, multi-functional glycans present in
human breast milk. They represent an intricate mix of heterogeneous structures which reach …

Interplay of human gut microbiome in health and wellness

N Singhvi, V Gupta, M Gaur, V Sharma, A Puri… - Indian journal of …, 2020 - Springer
The gut microbiome analysis, with specific interest on their direct impact towards the human
health, is currently revolutionizing the unexplored frontiers of the pathogenesis and …