The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During
the aging process, the dermis undergoes significant changes. Collagen, which is a major …

The rate of skin aging, or that of tissue in general, is determined by a variable predominance
of tissue degeneration over tissue regeneration. This review discusses the role of oxidative …

Oxygen in biology is essential for life. It comes at a cost during normal cellular function,
where reactive oxygen species (ROS) are generated by oxidative metabolism. Human skin …

Collagen-peptide supplementation could be an effective remedy to improve hydration,
elasticity, and wrinkling in human skin. The aim of this study was to conduct a double-blind …

▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

Ageing of human skin may result from both the passage of time (intrinsic ageing) and from
cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation …

Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core
surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as …

Skin is the largest organ of the body with important protective functions, which become
compromised with time due to both intrinsic and extrinsic ageing processes. Cellular …

The skin is increasingly exposed to ambient UV-irradiation thus increasing risks for
photooxidative damage with long-term detrimental effects like photoaging, characterized by …

The skin is increasingly exposed to ambient UV-irradiation thus increasing its risk for
photooxidative damage with longterm detrimental effects like photoaging, which is …